methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

Base Information

Chemical Name:methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate
CAS No.:1287261-42-0
Molecular Formula:C₂₈H₃₅N₃O₈
Molecular Weight:541.601
Hs Code.:

Synonyms:methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

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Chemical Property of methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

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Technology Process of methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

There total 7 articles about methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 15761-38-3
L-N-Boc-Ala

: 1287261-33-9
(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate

: 1287261-42-0
methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

Guidance literature:: L-N-Boc-Ala; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.25h;

(S)-methyl 2-((3-((4-methoxyphenyl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy) acetate; In tetrahydrofuran; for 8h;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-63-0
(S)-tert-butyl 7-(2-methoxy-2-oxoethoxy)-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-42-0
methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; trifluoroacetic acid / dichloromethane

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

2.2: 8 h

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm101605z

Reference yield:

: 1223620-39-0
(S)-tert-butyl 7-hydroxy-3-((4-methoxyphenyl)carbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

: 1287261-42-0
methyl 2-((S)-2-((S)-2-(tert-butoxycarbonylamino)propanoyl)-3-(4-methoxyphenylcarbamoyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide

2.1: triethylamine; trifluoroacetic acid / dichloromethane

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / tetrahydrofuran / 0.25 h / 20 °C

3.2: 8 h

With potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm101605z