8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

Base Information

Chemical Name:8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one
CAS No.:847573-93-7
Molecular Formula:C₃₂H₃₂N₄O₅
Molecular Weight:552.63
Hs Code.:

Synonyms:8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

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Chemical Property of 8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

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Technology Process of 8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

There total 10 articles about 8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 847573-85-7
N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(4-benzylpiperazin-1-yl)ethyl]-2-iodo-4,5-dimethoxybenzamide

: 847573-93-7
8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

Guidance literature:: With palladium diacetate; tris-(o-tolyl)phosphine; silver carbonate; In N,N-dimethyl-formamide; for 0.5h; Heating;
DOI:10.1021/jm049447z

Reference yield:

: 2759-28-6
1-phenylmethylpiperazine

: 847573-93-7
8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaI; K₂CO₃ / acetonitrile

2.1: LiAlH₄ / tetrahydrofuran

3.1: phenol / 2.5 h / Heating

3.2: 73 percent / phenol / 2.5 h / Heating

4.1: 1.32 g / Et₃N / CH₂Cl₂ / 16 h / Heating

5.1: 44 percent / Pd(OAc)2; P(o-tolyl)3; Ag₂CO₃ / dimethylformamide / 0.5 h / Heating

With palladium diacetate; lithium aluminium tetrahydride; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; silver carbonate; sodium iodide; phenol; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm049447z

Reference yield:

: 61203-48-3
2-iodo-4,5-dimethoxybenzoic acid

: 847573-93-7
8,9-dimethoxy-2,3-methylenedioxy-5-[2-(4-benzylpiperazin-1-yl)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / CH₂Cl₂ / 4 h / Heating

2: 1.32 g / Et₃N / CH₂Cl₂ / 16 h / Heating

3: 44 percent / Pd(OAc)2; P(o-tolyl)3; Ag₂CO₃ / dimethylformamide / 0.5 h / Heating

With palladium diacetate; oxalyl dichloride; triethylamine; tris-(o-tolyl)phosphine; silver carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049447z