N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide

Base Information

Chemical Name:N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide
CAS No.:1395412-80-2
Molecular Formula:C₂₀H₁₄ClF₃N₂O₂
Molecular Weight:406.792
Hs Code.:

Synonyms:N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide

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Chemical Property of N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide

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Technology Process of N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide

There total 3 articles about N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1395412-75-5
3-bromo-N-[4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-5-trifluoromethyl-benzamide

: 1395412-80-2
N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide

Guidance literature:: 3-bromo-N-[4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-5-trifluoromethyl-benzamide; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

With dihydrogen peroxide; acetic acid; In tetrahydrofuran; hexane; water; at 0 - 20 ℃;

With sodium hydrogencarbonate; In tetrahydrofuran; hexane; water; ethyl acetate;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1395412-80-2
N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 1 h / 100 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

2.2: 1 h / -78 °C

3.1: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / 1.5 h / -78 °C

3.2: 0 - 20 °C

With n-butyllithium; thionyl chloride; Triisopropyl borate; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;

Reference yield:

: 958258-15-6
3-bromo-5-(trifluoromethyl)benzoyl chloride

: 1395412-80-2
N-[4-(2-chloro-phenyl)-pyridin-3-yl]-3-hydroxy-N-methyl-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: 1 h / -78 °C

2.1: n-butyllithium; Triisopropyl borate / hexane; tetrahydrofuran / 1.5 h / -78 °C

2.2: 0 - 20 °C

With n-butyllithium; Triisopropyl borate; lithium hexamethyldisilazane; In tetrahydrofuran; hexane;