(S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester

Base Information

Chemical Name:(S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester
CAS No.:1056456-04-2
Molecular Formula:C₁₉H₂₃BrO₄S
Molecular Weight:427.359
Hs Code.:

Synonyms:(S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester

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Chemical Property of (S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester

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Technology Process of (S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester

There total 7 articles about (S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 222555-06-8
ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

: 1056456-04-2
(S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 20 °C

With N-Bromosuccinimide; di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide; 1: Mitsunobu reaction;

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 1056456-04-2
(S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium tert-butylate / toluene / 3 h / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h

3.1: Viscozyme L / 48 h / 20 °C / pH 7 / Phosphate buffer

3.2: pH 2 - 3

4.1: thionyl chloride / 3 h / Heating / reflux

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

6.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 20 °C

With N-Bromosuccinimide; thionyl chloride; Viscozyme L; di-isopropyl azodicarboxylate; potassium tert-butylate; hydrogen; triphenylphosphine; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5.1: Mitsunobu reaction;

Reference yield:

: 222835-03-2
3-(4-benzyloxy-phenyl)-2-ethoxy-acrylic acid ethyl ester

: 1056456-04-2
(S)-3-(4-((5-bromo-3-methylthiophen-2-yl)methoxy)phenyl)-2-ethoxypropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 12 h

2.1: Viscozyme L / 48 h / 20 °C / pH 7 / Phosphate buffer

2.2: pH 2 - 3

3.1: thionyl chloride / 3 h / Heating / reflux

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C

5.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 20 °C

With N-Bromosuccinimide; thionyl chloride; Viscozyme L; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium 10% on activated carbon; In ethanol; dichloromethane; N,N-dimethyl-formamide; 4.1: Mitsunobu reaction;