di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate

Base Information

• Chemical Name: di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate
• CAS No.: 1360628-01-8
• Molecular Formula: C₂₆H₃₃N₅O₄Si
• Molecular Weight: 507.665
• Mol file: 1360628-01-8.mol

Synonyms:di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate

Chemical Property of di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate

There total 3 articles about di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

tert-butyl (tert-butoxycarbonyl)[9-(4-iodophenyl)-9H-purin-6-yl]carbamate (917081-91-5) + trimethylsilylacetylene (1066-54-2) → di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate (1360628-01-8)

Guidance literature:

di(tert-butyl) 9-(4-iodophenyl)-9H-purin-6-yliminodicarbonate; trimethylsilylacetylene; With triethylamine; In N,N-dimethyl-formamide; for 0.333333h;

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 20 ℃; for 19h;

DOI:10.1021/jm201266b

Reference yield:

N6,N6-bis(tert-butoxycarbonyl)adenine (309947-86-2) → di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate (1360628-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper diacetate; triethylamine / N,N-dimethyl-formamide / Molecular sieve

2.1: triethylamine / N,N-dimethyl-formamide / 0.33 h

2.2: 19 h / 20 °C

With copper diacetate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm201266b

Reference yield:

4-iodophenylboronic acid (5122-99-6) → di-tert-butyl-9-(4-((trimethylsilyl)ethynyl)phenyl)-9H-purin-6-yliminodicarbonate (1360628-01-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: copper diacetate; triethylamine / N,N-dimethyl-formamide / Molecular sieve

2.1: triethylamine / N,N-dimethyl-formamide / 0.33 h

2.2: 19 h / 20 °C

With copper diacetate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm201266b

upstream raw materials:

tert-butyl (tert-butoxycarbonyl)[9-(4-iodophenyl)-9H-purin-6-yl]carbamate

trimethylsilylacetylene

4-iodophenylboronic acid

N⁶,N⁶-bis(tert-butoxycarbonyl)adenine

Downstream raw materials:

N₉-(4-ethynylphenyl)adenine