N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-L-threonine allyl ester

Base Information

• Chemical Name: N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-L-threonine allyl ester
• CAS No.: 301843-75-4
• Molecular Formula: C₃₇H₄₄N₂O₈Si
• Molecular Weight: 672.85
• Mol file: 301843-75-4.mol

Synonyms:N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-L-threonine allyl ester

Chemical Property of N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-L-threonine allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-L-threonine allyl ester

There total 2 articles about N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-L-threonine allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

succinic acid anhydride (108-30-5) + N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-aminobenzyl)dimethylsilyl-L-threonine allyl ester → N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-L-threonine allyl ester (301843-75-4)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(00)00588-3

Reference yield:

N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-threonine allyl ester (221325-38-8) → N-(9-fluorenylmethoxycarbonyl)-O-(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl-L-threonine allyl ester (301843-75-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / AcOH; Zn / tetrahydrofuran / 0.75 h / 20 °C

2: 98 percent / 4-methylmorpholine / CH₂Cl₂ / 3 h / 20 °C

With 4-methyl-morpholine; acetic acid; zinc; In tetrahydrofuran; dichloromethane; 1: Reduction / 2: Acylation;

DOI:10.1016/S0040-4020(00)00588-3

upstream raw materials:

succinic acid anhydride

N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-threonine allyl ester