(S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester

Base Information

Chemical Name:(S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester
CAS No.:1445781-88-3
Molecular Formula:C₂₆H₂₃FN₄O₆S
Molecular Weight:538.556
Hs Code.:

Synonyms:(S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester

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Chemical Property of (S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester

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Technology Process of (S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester

There total 6 articles about (S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445781-45-2
methyl 5-bromoquinoline-8-carboxylate

: 1445781-74-7
N-[(S)-2-amino-2-(3-fluoro-phenyl)-ethyl]-4-nitro-benzenesulfonamide

: 1445781-88-3
(S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester

Guidance literature:: With potassium phosphate; palladium diacetate; XPhos; In toluene; at 100 ℃; Microwave irradiation;

Reference yield:

: 885267-41-4
5-bromoquinoline-8-carboaldehyde

: 1445781-88-3
(S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: silver nitrate; sodium hydroxide / water; tetrahydrofuran / 0.5 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: potassium phosphate; XPhos; palladium diacetate / toluene / 100 °C / Microwave irradiation

With potassium phosphate; palladium diacetate; potassium carbonate; silver nitrate; sodium hydroxide; XPhos; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 611-32-5
8-methylquinoline

: 1445781-88-3
(S)-5-{1-(3-fluoro-phenyl)-2-[methyl-(4-nitro-benzenesulfonyl)-amino]-ethylamino}-quinoline-8-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: bromine; sulfuric acid; silver sulfate / water / 4 h / 0 - 20 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 12 h / 90 °C

3: silver nitrate / water; acetone / 6 h / 0 - 20 °C

4: silver nitrate; sodium hydroxide / water; tetrahydrofuran / 0.5 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

6: potassium phosphate; XPhos; palladium diacetate / toluene / 100 °C / Microwave irradiation

With potassium phosphate; N-Bromosuccinimide; sulfuric acid; bromine; palladium diacetate; potassium carbonate; silver sulfate; silver nitrate; sodium hydroxide; XPhos; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; acetone; toluene;