4-[(2-FORMYLPHENYL)(2,2,2-TRIFLUOROACETYL)AMINO]-BUT-2(E)-ENOIC ACID, METHYL ESTER

Base Information

Chemical Name:4-[(2-FORMYLPHENYL)(2,2,2-TRIFLUOROACETYL)AMINO]-BUT-2(E)-ENOIC ACID, METHYL ESTER
CAS No.:815632-52-1
Molecular Formula:C14H12 F3 N O4
Molecular Weight:0
Hs Code.:
Mol file:815632-52-1.mol

Synonyms:2-Butenoicacid, 4-[(2-formylphenyl)(trifluoroacetyl)amino]-, methyl ester, (2E)- (9CI)

Suppliers and Price of 4-[(2-FORMYLPHENYL)(2,2,2-TRIFLUOROACETYL)AMINO]-BUT-2(E)-ENOIC ACID, METHYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
4-[(2-FORMYLPHENYL)(2,2,2-TRIFLUOROACETYL)AMINO]-BUT-2(E)-ENOIC ACID METHYL ESTER 95.00%
5MG
$ 501.14

Total 0 raw suppliers

Chemical Property of 4-[(2-FORMYLPHENYL)(2,2,2-TRIFLUOROACETYL)AMINO]-BUT-2(E)-ENOIC ACID, METHYL ESTER

Chemical Property:

PSA：63.68000
LogP:2.12360

Purity/Quality:: 4-[(2-FORMYLPHENYL)(2,2,2-TRIFLUOROACETYL)AMINO]-BUT-2(E)-ENOIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-[(2-FORMYLPHENYL)(2,2,2-TRIFLUOROACETYL)AMINO]-BUT-2(E)-ENOIC ACID, METHYL ESTER

There total 1 articles about 4-[(2-FORMYLPHENYL)(2,2,2-TRIFLUOROACETYL)AMINO]-BUT-2(E)-ENOIC ACID, METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1117-71-1,56699-18-4,6000-00-6
methyl-4-bromo-2-butenoate

: 6203-15-2
2,2,2-trifluoro-N-(2-formylphenyl)acetamide

: 815632-52-1
4-[(2-formylphenyl)-(2,2,2-trifluoroacetyl)amino]but-2(E)-enoic acid methyl ester

Guidance literature:: 2,2,2-trifluoro-N-(2-formylphenyl)acetamide; With 18-crown-6 ether; sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

methyl-4-bromo-2-butenoate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;
DOI:10.1021/jm049619s

Reference yield:

: 815632-52-1
4-[(2-formylphenyl)-(2,2,2-trifluoroacetyl)amino]but-2(E)-enoic acid methyl ester

: 815632-53-2
4-{[2-(hydroxyiminomethyl)phenyl]-(2,2,2-trifluoroacetyl)amino}but-2(E)-enoic acid methyl ester

Guidance literature:: With pyridine; hydroxylamine hydrochloride; In ethanol; at 20 ℃; for 2h;
DOI:10.1021/jm049619s

Reference yield:

: 815632-52-1
4-[(2-formylphenyl)-(2,2,2-trifluoroacetyl)amino]but-2(E)-enoic acid methyl ester

: 5-acetyl-3-[4-(3-phenyl-2(E)-propen-1-yl)piperazin-1-ylmethyl]-3,3a,4,5-tetrahydroquinolino[4,3-c]isoxazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2.0 g / NH₂OH*HCl; pyridine / ethanol / 2 h / 20 °C

2.1: 60 percent / chloramine-T hydrate / ethanol / 2 h / 80 °C

3.1: NaBH₄ / tetrahydrofuran; H₂O / 0 - 20 °C

4.1: 0.64 g / PPh₃; CCl₄ / tetrahydrofuran / 3 h / Heating

5.1: 44 percent / butan-1-ol / 8 h / 120 °C

6.1: NaH; 18-crown-6 / tetrahydrofuran / 0.5 h / 20 °C

6.2: 40 percent / tetrahydrofuran / 3 h / 20 °C

With pyridine; tetrachloromethane; sodium tetrahydroborate; 18-crown-6 ether; hydroxylamine hydrochloride; chloroamine-T; sodium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1021/jm049619s