6203-15-2Relevant academic research and scientific papers
A Au(i)-catalyzed hydrogen bond-directed tandem strategy to synthesize indeno-chromen-4-one and indeno-quinolin-4-one derivatives
Jiang, Chongguo,Xiong, Zhiling,Jin, Shengfei,Gao, Peng,Tang, Yingzhan,Wang, Yanshi,Du, Chuan,Wang, Xiaoyu,Liu, Yang,Lin, Bin,Liu, Yongxiang,Cheng, Maosheng
supporting information, p. 11516 - 11519 (2016/10/03)
A gold-catalyzed hydrogen bond-directed tandem cyclization strategy to synthesize indeno-chromen-4-one and indeno-quinolin-4-one derivatives has been developed. The hydrogen bond existing between the hydroxyl group (or the amide group) and the carbonyl group played an essential role in controlling the selectivity, which was confirmed by both experimental and theoretical evidence.
Design, synthesis, and biological activity of oxime ether strobilurin derivatives containing indole moiety as novel fungicide
Xie, Ya-Qiang,Huang, Zi-Long,Yan, Hui-Dong,Li, Jun,Ye, Li-Yi,Che, Li-Ming,Tu, Song
, p. 743 - 755 (2015/05/27)
Twenty-one novel oxime ether strobilurins containing indole moiety, which employed an indole group to stabilize the E-styryl group in Enoxastrobin, were designed and synthesized. The biological assay indicated that most compounds exhibited potent fungicidal activities. The structure-activity relationship study demonstrated that the synthesized methyl 3-methoxypropenoate oxime ethers 7b-e exhibited remarkably high activities among all the synthesized oxime ether compounds 7. Moreover, the fungicidal activities of methyl α-(methoxyimino)benzeneacetate oxime ethers compounds 7f-i and N-methoxy-carbamic acid methyl esters compounds 7j-m showed significant differences compared to the corresponding products of ammonolysis.
A practical synthesis of 2-aroylindoles from N-(2-formylphenyl)trifluoro- acetamides in PEG-400
Zhao, Yu,Li, Deyao,Zhao, Liwen,Zhang, Jiancun
experimental part, p. 873 - 880 (2011/04/26)
A one-pot and environmentally benign approach to the synthesis of highly functionalized 3-unsubstituted 2-aroylindoles is described. Moderate to good yields were obtained through the reaction of easily accessible N-(2-formylphenyl)trifluoroacetamides and
Synthesis and in vivo evaluation of [11C]MPTQ: A potential PET tracer for alpha2A-adrenergic receptors
Prabhakaran, Jaya,Majo, Vattoly J.,Milak, Matthew S.,Mali, Pratap,Savenkova, Lyudmila,Mann, J. John,Parsey, Ramin V.,Kumar, J.S. Dileep
scheme or table, p. 3654 - 3657 (2010/09/04)
Radiosynthesis and in vivo evaluation of [N-methyl-11C] 5-methyl-3-[4-(3-phenylallyl)-piperazin-1-ylmethyl]-3,3a,4,5- tetrahydroisoxazolo[4,3-c]quinoline (1), a potential PET tracer for alpha2-adrenergic receptors is described. Syntheses of nonradioactive standard 1 and corresponding desmethyl precursor 2 were achieved from 2-aminobenzaldehyde in 40% and 65% yields, respectively. Methylation using [11C]CH 3I in presence of aqueous potassium hydroxide in DMSO afforded [ 11C]1 in 25% yield (EOS) with >99% chemical and radiochemical purities with a specific activity ranged from 3-4 Ci/μmol (n = 6). The total synthesis time was 30 min from EOB. PET studies in anesthetized baboon show that [11C]1 penetrates BBB and accumulates in alpha2A-AR enriched brain areas.
Cytotoxic compounds: derivatives of the pyrido [2,3,4-kl]acridine ring system
-
, (2008/06/13)
Compounds of formula (I), wherein X is selected from the group consisting of O, and NR3, where R3 represents a lower alkyl group; Y is selected from the group consisting of CH and N; R1 and R2 are independently
