3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea

Base Information

Chemical Name:3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea
CAS No.:1246249-44-4
Molecular Formula:C₂₄H₂₉N₅O₄
Molecular Weight:451.525
Hs Code.:

Synonyms:3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea

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Chemical Property of 3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea

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Technology Process of 3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea

There total 13 articles about 3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1246249-43-3
2-[4-(4-aminopiperidin-1-yl)phenyl]-5,7-dimethoxyquinazolin-4(3H)-one

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1246249-44-4
3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 42h; Reflux;

Reference yield:

: 1246249-38-6
N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide

: 1246249-44-4
3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 24 h / Reflux

2: triethylamine / tetrahydrofuran / 42 h / 20 °C / Reflux

With hydrogenchloride; triethylamine; In tetrahydrofuran;

Reference yield:

: 1158186-69-6
ethyl 4-(4-azidopiperidin-1-yl)benzoate

: 1246249-44-4
3-(1-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)piperidin-4-yl)-1,1-dimethylurea

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; palladium 10% on activated carbon; hydrogen / 1,4-dioxane; water / 5 h / 760.05 Torr

2: triethylamine / dichloromethane / 0.08 h / 20 °C

3: diisobutylaluminium hydride / dichloromethane; hexane / 1.33 h / -78 - 20 °C / Inert atmosphere

4: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 19 h / 20 °C / Molecular sieve

5: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 6 h / 155 °C

6: hydrogenchloride / 24 h / Reflux

7: triethylamine / tetrahydrofuran / 42 h / 20 °C / Reflux

With hydrogenchloride; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl acetamide; water;