N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide

Base Information

Chemical Name:N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide
CAS No.:1246249-38-6
Molecular Formula:C₂₃H₂₆N₄O₄
Molecular Weight:422.484
Hs Code.:

Synonyms:N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide

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Chemical Property of N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide

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Technology Process of N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide

There total 12 articles about N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 63920-73-0
2-amino-4,6-dimethoxybenzamide

: 1246249-41-1
N-[1-(4-formylphenyl)piperidin-4-yl]acetamide

: 1246249-38-6
N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 155 ℃; for 6h;

Reference yield: 29.0%

: 1044872-43-6
2-amino-4,6-dimethoxy-nicotinamide

: 1246249-41-1
N-[1-(4-formylphenyl)piperidin-4-yl]acetamide

: 1246249-38-6
N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide

Guidance literature:: With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 155 ℃; for 6h;

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 1246249-38-6
N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: dimethyl sulfoxide / 48 h / 120 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.08 h / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 5 h / 80 °C

4: acetic acid; palladium 10% on activated carbon; hydrogen / 1,4-dioxane; water / 5 h / 760.05 Torr

5: triethylamine / dichloromethane / 0.08 h / 20 °C

6: diisobutylaluminium hydride / dichloromethane; hexane / 1.33 h / -78 - 20 °C / Inert atmosphere

7: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 19 h / 20 °C / Molecular sieve

8: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 6 h / 155 °C

With sodium azide; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide;