(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester
CAS No.:148451-86-9
Molecular Formula:C₂₄H₂₈N₂O₅
Molecular Weight:424.497
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52289-93-7
o-Methoxybenzyl bromide

: 13139-14-5
Boc-Trp-OH

: 148451-86-9
(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester

Guidance literature:: With caesium carbonate; Multistep reaction; 1.) methanol, toluene, 2.) DMF;
DOI:10.1021/jm00066a015

Reference yield:

: 148451-86-9
(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester

: (S)-2-Amino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; for 16h;
DOI:10.1021/jm00035a006

Reference yield:

: 148451-86-9
(S)-2-tert-Butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester

: (S)-2-Benzoylamino-3-(1H-indol-3-yl)-propionic acid 2-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: saturated methanolic HCl / tetrahydrofuran / 16 h

2: pyridine / 16 h

With pyridine; hydrogenchloride; In tetrahydrofuran;
DOI:10.1021/jm00035a006