methyl 3-(4-cyanophenyl)-2-nitropropionate

Base Information

Chemical Name:methyl 3-(4-cyanophenyl)-2-nitropropionate
CAS No.:538342-15-3
Molecular Formula:C₁₁H₁₀N₂O₄
Molecular Weight:234.211
Hs Code.:

Synonyms:methyl 3-(4-cyanophenyl)-2-nitropropionate

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Chemical Property of methyl 3-(4-cyanophenyl)-2-nitropropionate

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Technology Process of methyl 3-(4-cyanophenyl)-2-nitropropionate

There total 3 articles about methyl 3-(4-cyanophenyl)-2-nitropropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-cyano-phenyl)-2-nitro-acrylic acid methyl ester

: 538342-15-3
methyl 3-(4-cyanophenyl)-2-nitropropionate

Guidance literature:: With sodium tetrahydroborate; silica gel; In chloroform; isopropyl alcohol; at 20 ℃;
DOI:10.1021/ja067682w

Reference yield:

: 2483-57-0
methyl 2-nitroacetate

: 105-07-7
4-cyanobenzaldehyde

: 538342-15-3
methyl 3-(4-cyanophenyl)-2-nitropropionate

Guidance literature:: methyl 2-nitroacetate; 4-cyanobenzaldehyde; With titanium tetrachloride; In tetrahydrofuran; tetrachloromethane; at 0 ℃;

With 4-methyl-morpholine; In tetrahydrofuran; tetrachloromethane; at 18 ℃;

With sodium tetrahydroborate; silica gel; In chloroform; isopropyl alcohol; at 20 ℃;
DOI:10.1021/ja0343151

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 538342-15-3
methyl 3-(4-cyanophenyl)-2-nitropropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TiCl₄ / tetrahydrofuran; CCl₄ / 0 °C

1.2: N-methylmorpholine / tetrahydrofuran; CCl₄ / 18 °C

2.1: SiO₂; NaBH₄ / CHCl₃; propan-2-ol / 20 °C

With sodium tetrahydroborate; silica gel; titanium tetrachloride; In tetrahydrofuran; tetrachloromethane; chloroform; isopropyl alcohol;
DOI:10.1021/ja067682w