(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

Base Information

Chemical Name:(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one
CAS No.:871589-86-5
Molecular Formula:C₃₄H₃₃F₇N₂O₄
Molecular Weight:666.636
Hs Code.:

(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

Synonyms:(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

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Chemical Property of (3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

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Technology Process of (3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

There total 19 articles about (3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871589-88-7
C₂₇H₂₅F₇N₄O₃

: 100-51-6,185532-71-2
benzyl alcohol

: 871589-86-5
(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

: (3S,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

: (3S,5S)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; dmap; In toluene; at 85 ℃; for 4 - 6h;

Reference yield:

: 871589-85-4
(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-carboxy-3-methylpyrrolidin-2-one

: 100-51-6,185532-71-2
benzyl alcohol

: 871589-86-5
(3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

: (3S,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

: (3S,5S)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-benzyloxycarboxylamino-3-methylpyrrolidin-2-one

Guidance literature:: (3R,5R)-5-(((1R),(2R),(3S))-3-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-2-(4-fluorophenyl)cyclopentan-1-yl)-3-carboxy-3-methylpyrrolidin-2-one; With sodium azide; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In water; acetone; at 0 - 20 ℃; for 1.41667h;

benzyl alcohol; dmap; at 85 ℃; for 3 - 4h;