N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

Base Information

Chemical Name:N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester
CAS No.:221332-90-7
Molecular Formula:C₂₉H₃₃NO₇S
Molecular Weight:539.65
Hs Code.:

Synonyms:N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

Suppliers and Price of N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

There total 1 articles about N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 174905-91-0
3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 221332-90-7
N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

Guidance literature:: With sodium carbonate; In benzene; at 8 - 10 ℃; for 0.5h;
DOI:10.1248/cpb.47.83

Reference yield: 99.0%

: 221332-90-7
N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

: 221333-06-8
(S)-N-<2-<3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>phenyl>-1-(hydroxymethyl)ethyl>-4-methoxybenzeneacetamide

Guidance literature:: With lithium borohydride; In tetrahydrofuran; for 1.5h; Ambient temperature;
DOI:10.1248/cpb.47.83

Reference yield:

: 221332-90-7
N-<(4-methoxyphenyl)acetyl>-3,5-dimethoxy-2-<<(4-methoxyphenyl)methyl>thio>-L-phenylalanine methyl ester

: (5S,10aS)-6,8-dimethoxy-5-<(4-methoxyphenyl)methyl>-1,5,10,10a-tetrahydroxazolo<3,4-b>isoquinolin-3(3H)-one

Guidance literature:: Multi-step reaction with 12 steps

1: 99 percent / LiBH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

2: 93 percent / pyridine / 1.5 h / Ambient temperature

3: 1.) POCl₃, 2.) NaBH₄ / 1.) toluene, reflux, 1.5 h, 2.) MeOH, -78 deg C, 1 h

4: 86 percent / aq. K₂CO₃ / methanol / 1 h / Ambient temperature

5: 91 percent / NaOEt / ethanol / 6 h / Heating

6: 90 percent / anisole, mercuric trifluoroacetate / ethanol / 14.5 h / Ambient temperature

7: 1.) NaH / 1.) DMF, RT, 2.) DMF, 100 deg C, 3 h

8: 82 percent / NaBH₄ / methanol / 1 h / Ambient temperature

9: SOCl₂ / 1 h / Ambient temperature

10: 1.) BuLi, diisopropylamine / 1.) THF, hexane, -78 deg C, 40 min, 2.) THF, hexane, a) -78 deg C, 2 h, b) -50 deg C, 20 h

11: 71 percent / 0.25N aq. HCl / methanol / 8.5 h / Ambient temperature

12: 83 percent / aq. MeOH / Raney Ni / 1 h / Heating

With pyridine; hydrogenchloride; methanol; sodium tetrahydroborate; lithium borohydride; n-butyllithium; thionyl chloride; sodium ethanolate; mercury(II) trifluoroacetate; sodium hydride; potassium carbonate; methoxybenzene; diisopropylamine; trichlorophosphate; nickel; In tetrahydrofuran; methanol; ethanol;
DOI:10.1248/cpb.47.83