N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Base Information

Chemical Name:N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide
CAS No.:1361330-11-1
Molecular Formula:C₂₇H₂₈F₂N₄O₅S
Molecular Weight:558.606
Hs Code.:

Synonyms:N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Suppliers and Price of N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

There total 7 articles about N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₀F₂N₄O₆S

: 1361330-11-1
N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: With methanol; potassium carbonate; In dichloromethane; for 2h; Inert atmosphere;

Reference yield:

: 608515-57-7
2,4-difluoro-6-methoxybenzaldehyde

: 1361330-11-1
N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: water / 3 h / 110 °C

2.1: hydrazine hydrate / butan-1-ol / 23 h / 110 - 115 °C

3.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C

3.2: 0.5 h / 20 °C

4.1: pyridine / 18 h / 21 °C / Inert atmosphere

5.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

6.1: triethylamine / dichloromethane / 2 h / Inert atmosphere

7.1: potassium carbonate; methanol / dichloromethane / 2 h / Inert atmosphere

With pyridine; methanol; lithium aluminium tetrahydride; potassium carbonate; hydrazine hydrate; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; butan-1-ol;

Reference yield:

: 1240518-42-6
6-fluoro-4-methoxy-1H-indazol-3-amine

: 1361330-11-1
N-[(3-{[6-fluoro-3-{[(3-fluoro-4-methylphenyl)sulfonyl]amino}-4-(methyloxy)-1H-indazol-1-yl]methyl}phenyl)methyl]-2-hydroxy-2-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: pyridine / 18 h / 21 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 2 h / 0 °C

4.1: triethylamine / dichloromethane / 2 h / Inert atmosphere

5.1: potassium carbonate; methanol / dichloromethane / 2 h / Inert atmosphere

With pyridine; methanol; lithium aluminium tetrahydride; potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;