(S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

Base Information

Chemical Name:(S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester
CAS No.:1400705-16-9
Molecular Formula:C₃₃H₄₃N₅O₇S
Molecular Weight:653.8
Hs Code.:

(S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

Synonyms:(S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

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Chemical Property of (S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

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Technology Process of (S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

There total 5 articles about (S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1400705-08-9
(S)-2-({2-[3-(3-hydroxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

: 97-72-3
2-Methylpropionic anhydride

: 1400705-16-9
(S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

Guidance literature:: With pyridine; at 20 ℃; for 1h;

Reference yield:

: 527-72-0
2-thiophenylcarboxylic acid

: 1400705-16-9
(S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C

3: triethylamine; sodium iodide / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

4: pyridine / 1 h / 20 °C

With pyridine; lithium hydroxide monohydrate; water; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1400863-17-3
(S)-3-amino-2-({2-[3-(3-hydroxy-phenyl)propoxy]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

: 1400705-16-9
(S)-2-({2-[3-(3-isobutyryloxy-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)-3-[(thiophene-2-carbonyl)amino]propionic acid 3-ethoxy-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

2: water; lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C

3: triethylamine; sodium iodide / N,N-dimethyl-formamide / 0.33 h / 120 °C / microwave irradiation

4: pyridine / 1 h / 20 °C

With pyridine; lithium hydroxide monohydrate; water; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;