4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

Base Information

Chemical Name:4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide
CAS No.:485387-01-7
Molecular Formula:C₃₆H₆₀N₆O₅S
Molecular Weight:688.976
Hs Code.:

Synonyms:4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

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Chemical Property of 4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

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Technology Process of 4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

There total 4 articles about 4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 109-01-3
1-methyl-piperazine

: 4-[2-methoxy-5-(chlorosulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

: 485387-01-7
4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

Guidance literature:: In water; at 5 ℃;
DOI:10.1021/jf0258050

Reference yield:

: 65446-29-9
2-methoxy-6-pentadecyl-benzoic acid methyl ester

: 485387-01-7
4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / tBuOK / dimethylsulfoxide / 70 °C

2: SOCl₂; DMF / hexane / Heating

3: 75 percent / Et₃N / CH₂Cl₂ / 0 - 5 °C

4: 75 percent / ClSO₃H / 0 - 5 °C

5: 59 percent / H₂O / 5 °C

With chlorosulfonic acid; thionyl chloride; potassium tert-butylate; triethylamine; N,N-dimethyl-formamide; In hexane; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1021/jf0258050

Reference yield:

: 38449-25-1
(15 : 0)-anacardic acid O-methyl ether

: 485387-01-7
4-[2-methoxy-5-(4-methylpiperazin-1-ylsulfonyl)-6-pentadecylbenzamido]-1-methyl-3-n-propylpyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂; DMF / hexane / Heating

2: 75 percent / Et₃N / CH₂Cl₂ / 0 - 5 °C

3: 75 percent / ClSO₃H / 0 - 5 °C

4: 59 percent / H₂O / 5 °C

With chlorosulfonic acid; thionyl chloride; triethylamine; N,N-dimethyl-formamide; In hexane; dichloromethane; water;
DOI:10.1021/jf0258050