(5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

Base Information

Chemical Name:(5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester
CAS No.:620116-56-5
Molecular Formula:C₃₄H₃₆O₉Si
Molecular Weight:616.74
Hs Code.:

(5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

Synonyms:(5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

Suppliers and Price of (5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

There total 6 articles about (5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 620116-55-4
(5S,6S)-5-(Dimethyl-phenyl-silanyl)-6-(3,4,5-trimethoxy-phenoxythiocarbonyloxymethyl)-5,6-dihydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid allyl ester

: 620116-56-5
(5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; In benzene; at 80 ℃; for 14h;
DOI:10.1021/ja0376588

Reference yield:

: 3839-31-4
dimethyl(phenyl)silyllithium

: 620116-56-5
(5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 3 h / -78 °C

1.2: tetrahydrofuran / -78 - 25 °C

1.3: 202.6 mg / aq. KHCO₃; aq. K₂CO₃ / methanol / 55 h / 25 °C

2.1: MeOTf / CH₂Cl₂ / 2 h / 25 °C

2.2: NaBH₄ / tetrahydrofuran; methanol / 0.5 h / 25 °C

2.3: 100 percent / (CO₂H)2*H₂O / tetrahydrofuran; H₂O / 16 h / 25 °C

3.1: 79 percent / Bu₃SnH; SiO₂ / toluene / 10 h / 80 °C

4.1: 99 percent / pyridine / CH₂Cl₂ / 2 h / 25 °C

5.1: 40 percent / tris(trimethylsilyl)silane; AIBN / benzene / 14 h / 80 °C

With pyridine; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; tri-n-butyl-tin hydride; silica gel; methyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; toluene; benzene;
DOI:10.1021/ja0376588

Reference yield:

: 4-isopropyl-2-naphtho[2,3-d][1,3]dioxol-6-yl-4,5-dihydro-oxazole

: 620116-56-5
(5S,5aS,8aR,9R)-5-(Dimethyl-phenyl-silanyl)-8-oxo-9-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5a-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 3 h / -78 °C

1.2: tetrahydrofuran / -78 - 25 °C

1.3: 202.6 mg / aq. KHCO₃; aq. K₂CO₃ / methanol / 55 h / 25 °C

2.1: MeOTf / CH₂Cl₂ / 2 h / 25 °C

2.2: NaBH₄ / tetrahydrofuran; methanol / 0.5 h / 25 °C

2.3: 100 percent / (CO₂H)2*H₂O / tetrahydrofuran; H₂O / 16 h / 25 °C

3.1: 79 percent / Bu₃SnH; SiO₂ / toluene / 10 h / 80 °C

4.1: 99 percent / pyridine / CH₂Cl₂ / 2 h / 25 °C

5.1: 40 percent / tris(trimethylsilyl)silane; AIBN / benzene / 14 h / 80 °C

With pyridine; 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; tri-n-butyl-tin hydride; silica gel; methyl trifluoromethanesulfonate; In tetrahydrofuran; dichloromethane; toluene; benzene;
DOI:10.1021/ja0376588