tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

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Chemical Name:tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate
CAS No.:1439395-44-4
Molecular Formula:C₂₇H₂₉N₅O₃
Molecular Weight:471.559
Hs Code.:

Synonyms:tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

There total 4 articles about tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1439395-35-3
tert-butyl 1-(4-(4-chloro-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

: 124-41-4
sodium methylate

: 1439395-44-4
tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

Guidance literature:: In methanol; at 20 ℃; Inert atmosphere;

Reference yield:

: 1439395-38-6
tert-butyl 1-(4-(6-chloro-5-iodopyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439395-44-4
tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.5 h / 80 °C / Inert atmosphere

2: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

3: methanol / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; copper(l) iodide; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; triethylamine; In 1,4-dioxane; methanol;

Reference yield:

: 1439395-40-0
tert-butyl 1-(4-(6-chloro-5-(pyridin-2-ylethynyl)pyrimidin-4-ylamino)phenyl)cyclobutylcarbamate

: 1439395-44-4
tert-butyl 1-(4-(4-methoxy-6-(pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium fluoride / 1,4-dioxane / 1 h / 130 °C / Inert atmosphere; Microwave irradiation

2: methanol / 20 °C / Inert atmosphere

With potassium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; methanol;