1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Base Information

Chemical Name:1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
CAS No.:1453847-99-8
Molecular Formula:C₂₂H₂₂ClFN₄O₃
Molecular Weight:444.893
Hs Code.:

Synonyms:1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Chemical Property of 1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

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Technology Process of 1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

There total 9 articles about 1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453853-22-9
1-((S)-2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)ethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453847-99-8
1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; water; for 0.5h;

Reference yield:

: 1453853-18-3
(S)-1-(2-(tert-butyldimethylsilyloxy)-1-(3-chlorophenyl)ethyl)-4-(2-(methylthio)pyrimidin-4-yl)pyridin-2(1H)-one

: 1453847-99-8
1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

2: N-ethyl-N,N-diisopropylamine / iso-butanol / 40 h / 120 °C / Sealed tube

3: hydrogenchloride / 1,4-dioxane; water; methanol / 0.5 h

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; dichloromethane; water; iso-butanol;

Reference yield:

: 17327-22-9
4-methoxy-2,6-dihydropyran

: 1453847-99-8
1-((S)-1-(3-chlorophenyl)-2-hydroxyethyl)-4-(2-(((3S,4S)-3-fluorotetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: Selectfluor / water; acetonitrile / 1.5 h / 0 °C / Cooling with ice

2.1: 1,2-dichloro-ethane / 0.17 h / 0 °C

2.2: 2 h

3.1: carbon dioxide; ammonium hydroxide / isopropyl alcohol / 40 °C / 75007.5 Torr

4.1: palladium on activated charcoal; hydrogen / methanol / 18 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / iso-butanol / 40 h / 120 °C / Sealed tube

6.1: hydrogenchloride / 1,4-dioxane; water; methanol / 0.5 h

With hydrogenchloride; ammonium hydroxide; carbon dioxide; palladium on activated charcoal; hydrogen; Selectfluor; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile; iso-butanol;