methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

Base Information

Chemical Name:methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate
CAS No.:1318898-75-7
Molecular Formula:C₅₁H₅₈N₈O₄
Molecular Weight:847.073
Hs Code.:

methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

Synonyms:methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

Suppliers and Price of methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

There total 8 articles about methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.4%

: 1007877-77-1
(R)-2-phenyl-2-(pyrrolidin-1-yl)acetic acid

: methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-[5-(6-{2-[(2S,4S)-4-methyl-2-pyrrolidinyl]-1H-imidazol-4-yl}-2-naphthalenyl)-1H-benzimidazol-2-yl]hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate dihydrochloride

: 1318898-75-7
methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

Guidance literature:: (R)-2-phenyl-2-(pyrrolidin-1-yl)acetic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.0333333h;

methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-[5-(6-{2-[(2S,4S)-4-methyl-2-pyrrolidinyl]-1H-imidazol-4-yl}-2-naphthalenyl)-1H-benzimidazol-2-yl]hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate dihydrochloride; In N,N-dimethyl-formamide;

Reference yield:

: 1590-25-6
1-(6-bromonaphthalen-2-yl)ethanone

: 1318898-75-7
methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; pyridinium hydrobromide perbromide / 0.17 h

1.2: 4 h

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2.2: 110 °C / Sealed tube

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

4.2: 2 h

4.3: 3 h / 80 °C

5.1: hydrogenchloride / 1,4-dioxane / 2 h

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.03 h

With hydrogenchloride; pyridinium hydrobromide perbromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 861880-64-0
6-bromo-N-methoxy-N-methyl-2-naphthamide

: 1318898-75-7
methyl ((1S)-2-methyl-1-{[(2S,3aS,6aS)-2-{5-[6-(2-{(2S,4S)-4-methyl-1-[(2R)-2-phenyl-2-(1-pyrrolidinyl)acetyl]-2-pyrrolidinyl}-1H-imidazol-4-yl)-2-naphthalenyl]-1H-benzimidazol-2-yl}hexahydrocyclopenta[b]pyrrol-1(2H)-yl]carbonyl}propyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 14 h / 0 - 20 °C

1.2: 0.17 h

2.1: acetic acid; pyridinium hydrobromide perbromide / 0.17 h

2.2: 4 h

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

3.2: 110 °C / Sealed tube

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h

5.2: 2 h

5.3: 3 h / 80 °C

6.1: hydrogenchloride / 1,4-dioxane / 2 h

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.03 h

With hydrogenchloride; pyridinium hydrobromide perbromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;