5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid

Base Information

• Chemical Name: 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid
• CAS No.: 911060-78-1
• Molecular Formula: C₁₈H₁₁F₃N₂O₃
• Molecular Weight: 360.292
• Mol file: 911060-78-1.mol

Synonyms:5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid

Chemical Property of 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid

There total 3 articles about 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H15F3N2O3 → 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (911060-78-1)

Guidance literature:

With water; sodium hydroxide; In ethanol;

DOI:10.1016/j.bmcl.2010.10.104

Reference yield:

5-Cyano-1H-indole-2-carboxylic acid ethyl ester (105191-13-7) → 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (911060-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 60 °C

2: water; potassium hydroxide / ethanol / 60 °C

With water; sodium hydride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.019

Reference yield:

3-(trifluoromethoxy)benzyl bromide (159689-88-0) → 5-cyano-1-(3-trifluoromethoxybenzyl)-1H-indole-2-carboxylic acid (911060-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 60 °C

2: water; potassium hydroxide / ethanol / 60 °C

With water; sodium hydride; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.02.019

upstream raw materials:

5-Cyano-1H-indole-2-carboxylic acid ethyl ester

3-(trifluoromethoxy)benzyl bromide

Downstream raw materials:

C₂₂H₂₀F₃N₃O₃

C₂₃H₂₃F₃N₄O₂

C₂₄H₂₄F₃N₃O₃

C₂₅H₂₇F₃N₄O₂