Technology Process of (2S,3S,5R)-3-Methyl-7-oxo-3-((E)-3-oxo-propenyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester
There total 7 articles about (2S,3S,5R)-3-Methyl-7-oxo-3-((E)-3-oxo-propenyl)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium perchlorate;
In
acetonitrile;
at -20 ℃;
for 4h;
DOI:10.1021/jm9601967
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaNO2, H+, KBr, 2.) CH3CO3H
2: 90 percent / PBu3 / methanol / 0.75 h / Ambient temperature
3: 84.2 percent / Heating
4: 1.) AcOAg, 2.) thiourea, pyridine / 1.) CH2Cl2, 6 h, 2.) DMF, from 0 deg C to RT
5: 1.) oxalyl chloride, DMSO, 2.) TEA / 1.) CH2Cl2, -70 deg C, 3 h, 2.) CH2Cl2, from -70 deg C to -10 deg C, 20 min
6: 13 percent / LiClO4 / acetonitrile / 4 h / -20 °C
With
pyridine; peracetic acid; oxalyl dichloride; tributylphosphine; TEA; silver(I) acetate; lithium perchlorate; hydrogen cation; dimethyl sulfoxide; thiourea; potassium bromide; sodium nitrite;
In
methanol; acetonitrile;
DOI:10.1021/jm9601967
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaNO2, H+, KBr, 2.) CH3CO3H
2: 90 percent / PBu3 / methanol / 0.75 h / Ambient temperature
3: 84.2 percent / Heating
4: 1.) AcOAg, 2.) thiourea, pyridine / 1.) CH2Cl2, 6 h, 2.) DMF, from 0 deg C to RT
5: 1.) oxalyl chloride, DMSO, 2.) TEA / 1.) CH2Cl2, -70 deg C, 3 h, 2.) CH2Cl2, from -70 deg C to -10 deg C, 20 min
6: 13 percent / LiClO4 / acetonitrile / 4 h / -20 °C
With
pyridine; peracetic acid; oxalyl dichloride; tributylphosphine; TEA; silver(I) acetate; lithium perchlorate; hydrogen cation; dimethyl sulfoxide; thiourea; potassium bromide; sodium nitrite;
In
methanol; acetonitrile;
DOI:10.1021/jm9601967
