(Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate

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Chemical Name:(Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate
CAS No.:796872-80-5
Molecular Formula:C₂₄H₃₇NO₄
Molecular Weight:403.562
Hs Code.:

Synonyms:(Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate

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Chemical Property of (Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate

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Technology Process of (Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate

There total 3 articles about (Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 100-52-7
benzaldehyde

: 796872-78-1
[1-(1-hydroxy-1-methylethyl)-4,4-dimethyl-1,2-pentadienyl] N,N-diisopropylcarbamate

: 796872-80-5
(Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate

Guidance literature:: [1-(1-hydroxy-1-methylethyl)-4,4-dimethyl-1,2-pentadienyl] N,N-diisopropylcarbamate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

benzaldehyde; In tetrahydrofuran; hexane; at -40 ℃; for 2.5h;
DOI:10.1021/ol0483908

Reference yield:

: diisopropyl-carbamic acid 4,4-dimethyl-pent-2-ynyl ester

: 796872-80-5
(Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi; TMEDA / 0.5 h / -78 °C

1.2: TIPT / 0.5 h / -78 °C

1.3: 92 percent / MeOH / 1 h / -78 °C

2.1: TMEDA; n-BuLi / diethyl ether; hexane / 0.5 h / -78 °C

2.2: 75 percent / diethyl ether; hexane / 2 h / -78 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

3.2: 79 percent / tetrahydrofuran; hexane / 2.5 h / -40 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ol0483908

Reference yield:

: 796872-77-0
diisopropyl-carbamic acid 4,4-dimethyl-penta-1,2-dienyl ester

: 796872-80-5
(Z)-3-(1-hydroxy-1-phenylmethyl)-1,1,5,5-tetramethyl-2-oxo-3-hexenyl N,N-diisopropylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMEDA; n-BuLi / diethyl ether; hexane / 0.5 h / -78 °C

1.2: 75 percent / diethyl ether; hexane / 2 h / -78 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 79 percent / tetrahydrofuran; hexane / 2.5 h / -40 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ol0483908