1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]

Base Information

Chemical Name:1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]
CAS No.:1575795-11-7
Molecular Formula:C₂₅H₂₄Cl₃F₃N₂O₂
Molecular Weight:547.832
Hs Code.:

Synonyms:1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]

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Chemical Property of 1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]

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Technology Process of 1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]

There total 7 articles about 1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1575811-13-0
5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]

: 79-31-2
isobutyric Acid

: 1575795-11-7
1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 12h;

Reference yield:

: C₁₄H₁₂Cl₄F₃NO₂

: 1575795-11-7
1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 2 h / Reflux

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 12 h / Inert atmosphere; Reflux

3: hydrogenchloride / methanol / 0.25 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 12 h / 20 °C

With hydrogenchloride; methanol; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; methanol; ethyl acetate; toluene;

Reference yield:

: 1072916-24-5
1-benzyl-3-(3,4,5-trichloro-phenyl)-3-trifluoromethyl-pyrrolidine

: 1575795-11-7
1-isobutyryl-5'-[3-(3,4,5-trichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-3'H-spiro[azetidine-3,1'-[2]benzofuran]

Guidance literature:: Multi-step reaction with 5 steps

1: 1,2-dichloro-ethane / 3 h / Reflux

2: methanol / 2 h / Reflux

3: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 12 h / Inert atmosphere; Reflux

4: hydrogenchloride / methanol / 0.25 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 12 h / 20 °C

With hydrogenchloride; methanol; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In tetrahydrofuran; methanol; ethyl acetate; 1,2-dichloro-ethane; toluene;