5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one

Base Information

Chemical Name:5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one
CAS No.:196299-10-2
Molecular Formula:C₂₀H₂₇FN₆O₃Si
Molecular Weight:446.557
Hs Code.:

Synonyms:5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one

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Chemical Property of 5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one

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Technology Process of 5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one

There total 9 articles about 5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 196299-10-2
5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one

Guidance literature:

Reference yield:

: 196299-08-8
3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-2-oxo-oxazolidin-5-ylmethyl methanesulfonate

: 196299-10-2
5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 65 ℃;
DOI:10.1021/jm990373e

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 196299-10-2
5-azidomethyl-3-{4-[4-(tert-butyl-dimethyl-silanyloxymethyl)-imidazol-1-yl]-3-fluoro-phenyl}-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 47 percent / K₂CO₃ / acetone / 24 h / Heating

2.1: 64 percent / imidazole / dimethylformamide / 0 - 20 °C

3.1: H₂ / tetrahydrofuran / 18 h

4.1: NaHCO₃ / tetrahydrofuran / 0 - 20 °C

5.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / -78 °C

5.2: tetrahydrofuran / -78 - 20 °C

6.1: NEt₃ / CH₂Cl₂ / 4 h / 20 °C

7.1: NaN₃ / dimethylformamide / 65 °C

With 1H-imidazole; sodium azide; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; 1.1: Substitution / 2.1: silylation / 3.1: Reduction / 4.1: Acylation / 5.1: Metallation / 5.2: Ring cleavage / 6.1: mesylation / 7.1: Substitution;
DOI:10.1021/jm990373e