4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide

Base Information

• Chemical Name: 4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide
• CAS No.: 362636-72-4
• Molecular Formula: C₁₈H₁₉F₃N₄O₂
• Molecular Weight: 380.37
• Mol file: 362636-72-4.mol

Synonyms:4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide

Chemical Property of 4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide

There total 7 articles about 4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-methyl-N-(1-methylethyl)benzamide (68289-10-1) + 4-methyl-2-(trifluoromethyl)pyrimidine-5-carboxylic acid (306960-74-7) → 4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide (362636-72-4)

Guidance literature:

4-methyl-2-(trifluoromethyl)pyrimidine-5-carboxylic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 1h; Heating / reflux;

2-amino-3-methyl-N-(1-methylethyl)benzamide; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

3-methyl-N-(1-methylethyl)-2-nitrobenzamide (362640-53-7) → 4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide (362636-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol

2: (i-Pr)2EtN / tetrahydrofuran / 0 - 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2005.08.034

Reference yield:

3-methyl-2-nitrobenzoic acid (5437-38-7) → 4-methyl-N-[2-methyl-6-[[(1-methylethyl)amino]carbonyl]phenyl]-2-(trifluoromethyl)-5-pyrimidinecarboxamide (362636-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: EtOCOCl; Et₃N / tetrahydrofuran / 10 °C

1.2: tetrahydrofuran

2.1: H₂ / Pd/C / ethanol

3.1: (i-Pr)2EtN / tetrahydrofuran / 0 - 20 °C

With hydrogen; chloroformic acid ethyl ester; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2005.08.034

upstream raw materials:

2-amino-3-methyl-N-(1-methylethyl)benzamide

4-methyl-2-trifluoromethylpyrimidine-5-carbonyl chloride

3-methyl-N-(1-methylethyl)-2-nitrobenzamide

4-methyl-2-trifluoromethyl-pyrimidine-5-carboxylic acid methyl ester