6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one

Base Information

Chemical Name:6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one
CAS No.:1598407-32-9
Molecular Formula:C₂₂H₂₀F₂O₃S
Molecular Weight:402.462
Hs Code.:

Synonyms:6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one

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Chemical Property of 6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one

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Technology Process of 6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one

There total 7 articles about 6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60811-24-7
3,4-difluorobenzenethiol

: 1598407-59-0
3-mesityl-6-(2-(methylsulfonyloxy)ethyl)-2-oxo-2H-pyran-4-yl pivalate

: 1598407-32-9
6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 50 ℃; for 2h;

Reference yield:

: 4408-60-0
2-mesitylacetic acid

: 1598407-32-9
6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 - -30 °C / Inert atmosphere

1.2: 2 h / -78 - 0 °C / Inert atmosphere; Cooling with ice

2.1: thionyl chloride / toluene / 1 h / Reflux

3.1: 5,5-dimethyl-1,3-cyclohexadiene / 8 h / Reflux

4.1: pyridine / 24 h / 10 - 30 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol / 1034.32 Torr

6.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

7.1: potassium carbonate / tetrahydrofuran / 2 h / 50 °C

With pyridine; n-butyllithium; thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol; hexane; toluene;

Reference yield:

: 144758-26-9
(chlorocarbonyl)-2,4,6-trimethylphenyl ketene

: 1598407-32-9
6-(2-(3,4-difluorophenylthio)ethyl)-4-hydroxy-3-mesityl-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 8 h / Reflux

2: pyridine / 24 h / 10 - 30 °C

3: palladium 10% on activated carbon; hydrogen / ethanol / 1034.32 Torr

4: triethylamine / tetrahydrofuran / 2 h / 0 °C

5: potassium carbonate / tetrahydrofuran / 2 h / 50 °C

With pyridine; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol;