N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide

Base Information

Chemical Name:N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide
CAS No.:1027205-10-2
Molecular Formula:C₂₈H₃₄N₄O₂
Molecular Weight:458.604
Hs Code.:

Synonyms:N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide

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Chemical Property of N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide

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Technology Process of N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide

There total 6 articles about N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8,3601-66-9,14675-97-9,33125-05-2
2-(tert-butoxycarbonylamino)-2-phenylacetic acid

: 1027205-10-2
N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) carbonyldiimidazole / 1.) dioxane, a) RT, 2.5 h, b) 45 deg C, 30 min, 2.) dioxane, RT, 16 h

2: anisole, trifluoroacetic acid / H₂O / a) 0 deg C, 1 h, b) RT, 2.5 h

3: borane methyl sulfide complex / tetrahydrofuran / 2 h / Heating

4: dimethylformamide / 16 h / Ambient temperature

With dimethylsulfide borane complex; methoxybenzene; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm950616c

Reference yield:

: 6850-57-3
2-methoxybenzylamine

: 1027205-10-2
N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) carbonyldiimidazole / 1.) dioxane, a) RT, 2.5 h, b) 45 deg C, 30 min, 2.) dioxane, RT, 16 h

2: anisole, trifluoroacetic acid / H₂O / a) 0 deg C, 1 h, b) RT, 2.5 h

3: borane methyl sulfide complex / tetrahydrofuran / 2 h / Heating

4: dimethylformamide / 16 h / Ambient temperature

With dimethylsulfide borane complex; methoxybenzene; 1,1'-carbonyldiimidazole; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm950616c

Reference yield:

: 2-(4-phenylpiperazin-1-yl)acetic acid sodium salt

: 1027205-10-2
N-[2-(2-Methoxy-benzylamino)-1-phenyl-ethyl]-2-(4-phenyl-piperazin-1-yl)-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine hydrobromide / 1.) DMF, 50 deg C, 35 min, 2.) DMF, RT, 3 h

2: dimethylformamide / 16 h / Ambient temperature

With triethylamine hydrobromide; In N,N-dimethyl-formamide;
DOI:10.1021/jm950616c