Technology Process of 1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine
There total 4 articles about 1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-(4-chlorophenyl)-1-methyl-1H-imidazole-4-carbonitrile; (3,5-difluorobenzyl)magnesium bromide;
In
diethyl ether; toluene;
at 0 - 20 ℃;
for 1h;
With
sodium tetrahydroborate;
In
methanol; diethyl ether; toluene; iso-butanol;
at 0 ℃;
for 0.333333h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / acetonitrile / 0.33 h / 0 °C
2.1: pyridine / N,N-dimethyl-formamide / 0.58 h / 200 °C / Microwave irradiation
3.1: diethyl ether; toluene / 1 h / 0 - 20 °C
3.2: 0.33 h / 0 °C
With
pyridine; N-Bromosuccinimide;
In
diethyl ether; N,N-dimethyl-formamide; toluene; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; caesium carbonate / N,N-dimethyl-formamide / 15 h / 120 °C
2.1: N-Bromosuccinimide / acetonitrile / 0.33 h / 0 °C
3.1: pyridine / N,N-dimethyl-formamide / 0.58 h / 200 °C / Microwave irradiation
4.1: diethyl ether; toluene / 1 h / 0 - 20 °C
4.2: 0.33 h / 0 °C
With
pyridine; N-Bromosuccinimide; tricyclohexylphosphine tetrafluoroborate; palladium diacetate; caesium carbonate;
In
diethyl ether; N,N-dimethyl-formamide; toluene; acetonitrile;
