1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine

Base Information

Chemical Name:1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine
CAS No.:1620231-88-0
Molecular Formula:C₁₈H₁₆ClF₂N₃
Molecular Weight:347.795
Hs Code.:

Synonyms:1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine

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Chemical Property of 1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine

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Technology Process of 1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine

There total 4 articles about 1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620231-87-9
5-(4-chlorophenyl)-1-methyl-1H-imidazole-4-carbonitrile

: (3,5-difluorobenzyl)magnesium bromide

: 1620231-88-0
1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine

Guidance literature:: 5-(4-chlorophenyl)-1-methyl-1H-imidazole-4-carbonitrile; (3,5-difluorobenzyl)magnesium bromide; In diethyl ether; toluene; at 0 - 20 ℃; for 1h;

With sodium tetrahydroborate; In methanol; diethyl ether; toluene; iso-butanol; at 0 ℃; for 0.333333h;

Reference yield:

: 1111266-89-7
5-(4-chlorophenyl)-1-methyl-1H-imidazole

: 1620231-88-0
1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide / acetonitrile / 0.33 h / 0 °C

2.1: pyridine / N,N-dimethyl-formamide / 0.58 h / 200 °C / Microwave irradiation

3.1: diethyl ether; toluene / 1 h / 0 - 20 °C

3.2: 0.33 h / 0 °C

With pyridine; N-Bromosuccinimide; In diethyl ether; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 637-87-6
1-Chloro-4-iodobenzene

: 1620231-88-0
1-(5-(4-chlorophenyl)-methyl-1H-imidazol-4-yl)-2-(3,5-difluorophenyl)ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium diacetate; tricyclohexylphosphine tetrafluoroborate; caesium carbonate / N,N-dimethyl-formamide / 15 h / 120 °C

2.1: N-Bromosuccinimide / acetonitrile / 0.33 h / 0 °C

3.1: pyridine / N,N-dimethyl-formamide / 0.58 h / 200 °C / Microwave irradiation

4.1: diethyl ether; toluene / 1 h / 0 - 20 °C

4.2: 0.33 h / 0 °C

With pyridine; N-Bromosuccinimide; tricyclohexylphosphine tetrafluoroborate; palladium diacetate; caesium carbonate; In diethyl ether; N,N-dimethyl-formamide; toluene; acetonitrile;