Technology Process of 7β,10β-(d6)-dimethoxydocetaxel-2’-O-alaninate
There total 5 articles about 7β,10β-(d6)-dimethoxydocetaxel-2’-O-alaninate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
10% palladium hydroxide on charcoal; hydrogen;
In
tetrahydrofuran;
for 5h;
under 2068.65 Torr;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dmap; dicyclohexyl-carbodiimide / ethyl acetate / 20 °C / Molecular sieve; Inert atmosphere
2: hydrogenchloride / ethanol / 0 °C / Inert atmosphere
3: dmap; diisopropyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere
4: hydrogen; 10% palladium hydroxide on charcoal / tetrahydrofuran / 5 h / 2068.65 Torr
With
hydrogenchloride; dmap; 10% palladium hydroxide on charcoal; hydrogen; dicyclohexyl-carbodiimide; diisopropyl-carbodiimide;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride / ethanol / 0 °C / Inert atmosphere
2: dmap; diisopropyl-carbodiimide / dichloromethane / 0 - 20 °C / Inert atmosphere
3: hydrogen; 10% palladium hydroxide on charcoal / tetrahydrofuran / 5 h / 2068.65 Torr
With
hydrogenchloride; dmap; 10% palladium hydroxide on charcoal; hydrogen; diisopropyl-carbodiimide;
In
tetrahydrofuran; ethanol; dichloromethane;
