3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester

Base Information

Chemical Name:3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester
CAS No.:185744-61-0
Molecular Formula:C₃₂H₃₄N₄O₉
Molecular Weight:618.643
Hs Code.:

Synonyms:3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester

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Chemical Property of 3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester

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Technology Process of 3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester

There total 4 articles about 3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: 67-64-1
acetone

: 474081-20-4
3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-hydroxy-hexanoic acid

: 185744-61-0
3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester

Guidance literature:: With sulfuric acid; chromic acid; at 0 ℃; for 1h;
DOI:10.1021/jm011110z

Reference yield:

: 14611-34-8
N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginine

: 185744-61-0
3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester

Guidance literature:: Multi-step reaction with 5 steps

1: 88.8 percent / TBTU; Et₃N / CH₂Cl₂ / 1 h / 20 °C / pH 8

2: diisobutylaluminumhydride / CH₂Cl₂ / 1 h / -78 °C

3: 17 g / aq. triethylbenzylammonium chloride / CH₂Cl₂ / 0.5 h / 0 - 5 °C

4: 100 percent / HCl / methanol; diethyl ether / 16 h / 5 °C

5: 90.7 percent / aq. H₂SO₄; chromic acid / 1 h / 0 °C

With hydrogenchloride; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; chromic acid; diisobutylaluminium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm011110z

Reference yield:

: 139033-47-9
Z-Arg-(Z₂)-H

: 185744-61-0
3-(benzyloxycarbonylamino)-6-(dibenzyloxycarbonylguanidino)-2-oxo-hexanoic acid methylester

Guidance literature:: Multi-step reaction with 3 steps

1: 17 g / aq. triethylbenzylammonium chloride / CH₂Cl₂ / 0.5 h / 0 - 5 °C

2: 100 percent / HCl / methanol; diethyl ether / 16 h / 5 °C

3: 90.7 percent / aq. H₂SO₄; chromic acid / 1 h / 0 °C

With hydrogenchloride; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; chromic acid; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm011110z