tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

Base Information

Chemical Name:tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate
CAS No.:852661-67-7
Molecular Formula:C₂₄H₃₉FN₂O₃
Molecular Weight:422.584
Hs Code.:

Synonyms:tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

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Chemical Property of tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

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Technology Process of tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

There total 6 articles about tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852661-66-6
tert-butyl ((1R,2S)-3-{[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 852661-67-7
tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

Guidance literature:: tert-butyl ((1R,2S)-3-{[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate; cyclohexanone; In methanol; at 20 ℃; for 2h; Molecular sieve;

With sodium cyanoborohydride; In methanol;

With sodium hydroxide; sodium cyanoborohydride; acetic acid; more than 3 stages;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852661-67-7
tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

2.2: 1 h

3.1: lithium trifluoromethanesulfonate / acetonitrile

4.1: methanol / 2 h / 20 °C / Molecular sieve

With lithium aluminium tetrahydride; hydrogen; lithium trifluoromethanesulfonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; acetonitrile;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 852661-67-7
tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

3.2: 1 h

4.1: lithium trifluoromethanesulfonate / acetonitrile

5.1: methanol / 2 h / 20 °C / Molecular sieve

With lithium aluminium tetrahydride; hydrogen; lithium trifluoromethanesulfonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; toluene; acetonitrile;