(2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Base Information

Chemical Name:(2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol
CAS No.:852661-68-8
Molecular Formula:C₁₉H₃₁FN₂O
Molecular Weight:322.466
Hs Code.:

Synonyms:(2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

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Technology Process of (2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

There total 7 articles about (2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852661-67-7
tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate

: 852661-68-8
(2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: tert-butyl ((1R,2S)-3-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}-2-hydroxy-1-methylpropyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

With sodium hydroxide; In water; at 20 ℃; for 0.5h;

Reference yield:

: C₃₃H₄₃FN₂O

: 852661-68-8
(2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: With hydrogen; acetic acid; palladium dihydroxide; In methanol;
DOI:10.1016/j.bmcl.2007.11.087

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852661-68-8
(2S,3R)-3-amino-1-{cyclohexyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

2.2: 1 h

3.1: lithium trifluoromethanesulfonate / acetonitrile

4.1: methanol / 2 h / 20 °C / Molecular sieve

5.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

5.2: 0.5 h / 20 °C

With lithium aluminium tetrahydride; hydrogen; lithium trifluoromethanesulfonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;