2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

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Chemical Name:2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol
CAS No.:1073186-70-5
Molecular Formula:C₂₇H₄₂N₂O₅S₂
Molecular Weight:538.773
Hs Code.:

Synonyms:2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

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Chemical Property of 2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

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Technology Process of 2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

There total 8 articles about 2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1073186-69-2
5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(2-hydroxy-ethyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid

: 1073186-70-5
2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

Guidance literature:: 5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(2-hydroxy-ethyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid; With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h;

With sodium dihydrogenphosphate; water; In tetrahydrofuran;

Reference yield:

: 1073186-91-0
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

: 1073186-70-5
2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.25 h

2.1: dmap; triethylamine / dichloromethane / 3 h

3.1: hydrogenchloride / 1,4-dioxane / 3 h

4.1: triethylamine / dichloromethane / 0.08 h

4.2: 3 h / 20 °C

5.1: methanol; sodium hydroxide; water / 15 h / 20 °C

5.2: 0 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h

With hydrogenchloride; methanol; dmap; sodium hydroxide; lithium aluminium tetrahydride; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1073186-92-1
4-(2-acetoxy-ethyl)-4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1073186-70-5
2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 3 h

2.1: triethylamine / dichloromethane / 0.08 h

2.2: 3 h / 20 °C

3.1: methanol; sodium hydroxide; water / 15 h / 20 °C

3.2: 0 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h

With hydrogenchloride; methanol; sodium hydroxide; lithium aluminium tetrahydride; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;