4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1073186-91-0
Molecular Formula:C₂₈H₄₅NO₅S
Molecular Weight:507.735
Hs Code.:

Synonyms:4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate: 135716-08-4
tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate

: 1073186-91-0
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With piperidine; at 90 ℃; for 15h;

Reference yield:

: 1073186-91-0
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

: C₂₆H₄₃NO₄S

Guidance literature:: 4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; for 1.25h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1073186-91-0
4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-ethoxycarbonylmethyl-piperidine-1-carboxylic acid tert-butyl ester

: 1073186-70-5
2,6-di-tert-butyl-4-[4-(2-hydroxy-ethyl)-1-(5-hydroxymethyl-1-methyl-1H-pyrrole-2-sulfonyl)-piperidin-4-ylsulfanyl]-phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.25 h

2.1: dmap; triethylamine / dichloromethane / 3 h

3.1: hydrogenchloride / 1,4-dioxane / 3 h

4.1: triethylamine / dichloromethane / 0.08 h

4.2: 3 h / 20 °C

5.1: methanol; sodium hydroxide; water / 15 h / 20 °C

5.2: 0 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h

With hydrogenchloride; methanol; dmap; sodium hydroxide; lithium aluminium tetrahydride; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane;