5-amino-4-carboxamido-1(2',3'-O-isopropylidene-5-O-t-butyldiphenyl silyl β-D-ribofuranosyl)-vic triazole

Base Information

Chemical Name:5-amino-4-carboxamido-1(2',3'-O-isopropylidene-5-O-t-butyldiphenyl silyl β-D-ribofuranosyl)-vic triazole
CAS No.:82631-10-5
Molecular Formula:C₂₇H₃₅N₅O₅Si
Molecular Weight:537.691
Hs Code.:

Synonyms:5-amino-4-carboxamido-1(2',3'-O-isopropylidene-5-O-t-butyldiphenyl silyl β-D-ribofuranosyl)-vic triazole

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Chemical Property of 5-amino-4-carboxamido-1(2',3'-O-isopropylidene-5-O-t-butyldiphenyl silyl β-D-ribofuranosyl)-vic triazole

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Technology Process of 5-amino-4-carboxamido-1(2',3'-O-isopropylidene-5-O-t-butyldiphenyl silyl β-D-ribofuranosyl)-vic triazole

There total 1 articles about 5-amino-4-carboxamido-1(2',3'-O-isopropylidene-5-O-t-butyldiphenyl silyl β-D-ribofuranosyl)-vic triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: ((3aR,4R,6S,6aR)-6-Azido-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethoxy)-tert-butyl-diphenyl-silane

: 107-91-5
cyanoacetic acid amide

: 82631-10-5
5-amino-4-carboxamido-1(2',3'-O-isopropylidene-5-O-t-butyldiphenyl silyl β-D-ribofuranosyl)-vic triazole

Guidance literature:: With potassium hydroxide; In water; N,N-dimethyl-formamide; 0 deg C warm up to RT;
DOI:10.1016/0040-4020(82)85051-5

Reference yield:

: 82631-10-5
5-amino-4-carboxamido-1(2',3'-O-isopropylidene-5-O-t-butyldiphenyl silyl β-D-ribofuranosyl)-vic triazole

: 4968-68-7
3-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) NH₃ / 1.) 100 deg C, 3h, 2.) MeOH, RT, 15 h

2: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

3: 90 percent / tetrahydrofuran; H₂O / 96 h / Ambient temperature; Dowex 50 H⁽¹⁺⁾resin

With tetrabutyl ammonium fluoride; ammonia; In tetrahydrofuran; water;
DOI:10.1016/0040-4020(82)85051-5