N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide

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Chemical Name:N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide
CAS No.:1260432-25-4
Molecular Formula:C₂₄H₂₂F₂N₆O₂
Molecular Weight:464.474
Hs Code.:

Synonyms:N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide

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Chemical Property of N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide

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Technology Process of N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide

There total 5 articles about N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 98-96-4
pyrazinamide

: 1260432-17-4
2-(3-bromophenyl)-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-4-amine

: 1260432-25-4
N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide

Guidance literature:: With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; at 150 ℃; for 1h; Sealed tube; Inert atmosphere; Mirowave irradiation;

Reference yield:

: 4198-90-7
3,5-dimethyl-4-hydroxybenzonitrile

: 1260432-25-4
N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / isopropyl alcohol; water / -78 - 40 °C / Cooling with ice

2.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C

3.1: methanol / 40 - 60 °C

4.1: ammonia / methanol / 48 h / 40 - 45 °C

5.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 1 h / 150 °C / Sealed tube; Inert atmosphere; Mirowave irradiation

With n-butyllithium; ammonia; caesium carbonate; sodium hydroxide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; diethyl ether; water; isopropyl alcohol;

Reference yield:

: 1260433-21-3
2-(3-bromophenyl)-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-4-methyl-1H-imidazole-5(2H)-thione

: 1260432-25-4
N-(3-(4-amino-2-(4-(difluoromethoxy)-3,5-dimethylphenyl)-5-methyl-2H-imidazol-2-yl)phenyl)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / methanol / 48 h / 40 - 45 °C

2: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 1 h / 150 °C / Sealed tube; Inert atmosphere; Mirowave irradiation

With ammonia; caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol;