5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

Base Information

Chemical Name:5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole
CAS No.:1384951-39-6
Molecular Formula:C₂₃H₂₄ClN₅O₃S
Molecular Weight:485.994
Hs Code.:

Synonyms:5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

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Chemical Property of 5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

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Technology Process of 5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

There total 6 articles about 5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1384951-83-0
7-bromo-4-[1-(3-isopropyl[1,2,4]oxadiazol-5-yl)piperidin-4-yloxy]thieno[3,2-d]pyrimidine

: 219735-99-6
2-chloro-4-methoxyphenylboronic acid

: 1384951-39-6
5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 12h; Inert atmosphere;

Reference yield:

: 31169-25-2
7-bromothieno[3,2-d]pyrimidine-4(3H)-one

: 1384951-39-6
5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 3 h / 150 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 2 h / 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

With sodium hydride; sodium carbonate; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1384951-39-6
5-(4-(7-(2-chloro-4-methoxyphenyl)thieno[3,2-d]pyrimidin-4-yloxy)piperidin-1-yl)-3-isopropyl-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 2.5 h / 0 - 20 °C

2.1: zinc(II) chloride / ethyl acetate; tetrahydrofuran / 2 h

2.2: 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 2 h / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / 100 °C / Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; sodium carbonate; zinc(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;