4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine

Base Information

• Chemical Name: 4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine
• CAS No.: 433225-94-6
• Molecular Formula: C₂₀H₁₆F₄N₄O₂
• Molecular Weight: 420.366

Synonyms:4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine

Chemical Property of 4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine

Chemical Property:

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Technology Process of 4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine

There total 4 articles about 4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-2-nitroaniline (433225-93-5) → 4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine (433225-94-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 72h;

DOI:10.1021/jm0611051

Reference yield:

5-chloro-2-nitroaniline (1635-61-6) → 4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine (433225-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 90 °C

2: 21.6 g / tetrahydrofuran / 20 °C

3: 13.0 g / H₂ / Pd/C / ethanol / 72 h

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0611051

Reference yield:

3,4'-diamino-4-nitrodiphenyl ether (30491-74-8) → 4-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)phenylene-1,2-diamine (433225-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 21.6 g / tetrahydrofuran / 20 °C

2: 13.0 g / H₂ / Pd/C / ethanol / 72 h

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jm0611051

upstream raw materials:

5-(4-((2-fluoro-5-(trifluoromethyl)phenyl)aminocarbonylamino)phenoxy)-2-nitroaniline

5-chloro-2-nitroaniline

3,4'-diamino-4-nitrodiphenyl ether

4-amino-phenol

Downstream raw materials:

C₂₁H₁₅F₄N₅O₂

N-(6-{4-[3-(2-fluoro-5-trifluoromethyl-phenyl)-ureido]-phenoxy}-1H-benzoimidazol-2-yl)-2-(4-methyl-piperazin-1-yl)-acetamide

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