4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine

Base Information

Chemical Name:4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine
CAS No.:937701-43-4
Molecular Formula:C₂₆H₃₇NO₄Si
Molecular Weight:455.67
Hs Code.:

Synonyms:4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine

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Chemical Property of 4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine

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Technology Process of 4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine

There total 5 articles about 4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 937701-63-8
tert-butyl-(2-{2-[2-(4-iodophenoxy)ethoxy]ethoxy}ethoxy)dimethylsilane

: 14235-81-5
4-Ethynylaniline

: 937701-43-4
4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine

Guidance literature:: With ammonium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/jm070090j

Reference yield:

: 187662-48-2
2-(2-(2-(4-iodophenoxy)ethoxy)ethoxy)ethan-1-ol

: 937701-43-4
4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / imidazole / dimethylformamide / 16 h / 20 °C

2: 66 percent / aq. NH₃ / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; ammonium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Sonogashira reaction;
DOI:10.1021/jm070090j

Reference yield:

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 937701-43-4
4-(4-(2-(2-(2-(tert-butyldimethylsilanyloxy)ethoxy)ethoxy)ethoxy)phenylethynyl)phenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NaI; Cs₂CO₃ / dimethylformamide / 16 h / 110 °C

2: 92 percent / imidazole / dimethylformamide / 16 h / 20 °C

3: 66 percent / aq. NH₃ / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 4 h / 20 °C

With 1H-imidazole; ammonium hydroxide; caesium carbonate; sodium iodide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; N,N-dimethyl-formamide; 3: Sonogashira reaction;
DOI:10.1021/jm070090j