2-iodo-2-methyl-3-tosylbutane

Base Information

• Chemical Name: 2-iodo-2-methyl-3-tosylbutane
• CAS No.: 71963-98-9
• Molecular Formula: C₁₂H₁₇IO₂S
• Molecular Weight: 352.236
• Mol file: 71963-98-9.mol

Synonyms:2-iodo-2-methyl-3-tosylbutane

Chemical Property of 2-iodo-2-methyl-3-tosylbutane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-iodo-2-methyl-3-tosylbutane

There total 4 articles about 2-iodo-2-methyl-3-tosylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-methyl-but-2-ene (513-35-9) + p-toluenesulfonyl iodide (1950-78-3) → 2-iodo-2-methyl-3-tosylbutane (71963-98-9)

Guidance literature:

With triethylaminium halide; copper dichloride; In acetonitrile; at 0 ℃;

DOI:10.1021/jo01291a006

Reference yield:

sodium 4-methylbenzenesulfinate (824-79-3) → 2-iodo-2-methyl-3-tosylbutane (71963-98-9)

Guidance literature:

Multi-step reaction with 2 steps

1: I₂ / ethanol; H₂O

2: 92 percent / CuCl₂, triethylaminium halide / acetonitrile / 0 °C

With triethylaminium halide; iodine; copper dichloride; In ethanol; water; acetonitrile;

DOI:10.1021/jo01291a006

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 2-iodo-2-methyl-3-tosylbutane (71963-98-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / Na₂SO₃, NaHCO₃ / H₂O / 2 h / 70 - 80 °C

2: I₂ / ethanol; H₂O

3: 92 percent / CuCl₂, triethylaminium halide / acetonitrile / 0 °C

With triethylaminium halide; iodine; sodium hydrogencarbonate; copper dichloride; sodium sulfite; In ethanol; water; acetonitrile;

DOI:10.1021/jo01291a006

upstream raw materials:

2-methyl-but-2-ene

p-toluenesulfonyl iodide

sodium p-toluenesulfinate tetrahydrate

sodium 4-methylbenzenesulfinate

Downstream raw materials:

1-methyl-4-((3-methylbut-2-en-2-yl)sulfonyl)benzene

Refernces

• 1、 Liu, Lilian Kao,Chi, Y.,Jen, Kwan-Yue. "Copper-Catalyzed Additions of Sulfonyl Iodides to Simple and Cyclic Alkenes". . p. 406 - 410. Retrieved 2007/10/02.