(4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone

Base Information

Chemical Name:(4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone
CAS No.:1355969-44-6
Molecular Formula:C₂₁H₁₂ClN₃O₃S₂
Molecular Weight:453.93
Hs Code.:

Synonyms:(4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone

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Chemical Property of (4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone

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Technology Process of (4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone

There total 5 articles about (4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 40899-71-6
1-benzenesulfonylindole

: 86762-06-3
4-chlorothieno[2,3-d]pyrimidine-6-carbonyl chloride

: 1355969-44-6
(4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone

Guidance literature:: 1-benzenesulfonylindole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

4-chlorothieno[2,3-d]pyrimidine-6-carbonyl chloride; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.11.023

Reference yield:

: 14080-59-2
4-chlorothieno[2,3-d]pyrimidine

: 1355969-44-6
(4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

1.3: Inert atmosphere

2.1: thionyl chloride / 3 h / Inert atmosphere; Reflux

3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C / Inert atmosphere

With n-butyllithium; thionyl chloride; In tetrahydrofuran; hexane;
DOI:10.1016/j.bmc.2011.11.023

Reference yield:

: 120-72-9
indole

: 1355969-44-6
(4-chlorothieno[2,3-d]pyrimidin-6-yl)(1-(phenylsulfonyl)-1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; mineral oil;
DOI:10.1016/j.bmc.2011.11.023