N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide

Base Information

• Chemical Name: N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide
• CAS No.: 152675-28-0
• Molecular Formula: C₁₆H₁₂ClN₃O₂
• Molecular Weight: 313.743
• Mol file: 152675-28-0.mol

Synonyms:N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide

Chemical Property of N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide

There total 4 articles about N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-amino-2-phenylquinazolin-4(3H)-one (1904-60-5) + chloroacetyl chloride (79-04-9) → N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide (152675-28-0)

Guidance literature:

With triethylamine; In 1,4-dioxane; at 20 ℃; for 1.5h; Reflux;

DOI:10.1515/znb-2015-0035

Reference yield:

2-phenyl-4H-3,1-benzoxazin-4-one (1022-46-4) → N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide (152675-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 3 h / Reflux

2: triethylamine / 1,4-dioxane / 1.5 h / 20 °C / Reflux

With hydrazine hydrate; triethylamine; In 1,4-dioxane; ethanol;

DOI:10.1515/znb-2015-0035

Reference yield:

2-(Benzoylamino)benzoic Acid (579-93-1) → N-(2-phenyl-3,4-dihydro-4-oxoquinazolin-3-yl)chloroacetamide (152675-28-0)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic anhydride / Reflux

2: hydrazine hydrate / butan-1-ol / 8 h / Reflux

3: N,N-dimethyl-formamide / 12 h

With acetic anhydride; hydrazine hydrate; In N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1016/j.bioorg.2019.103422 DOI:10.1016/j.bioorg.2020.104532

upstream raw materials:

3-amino-2-phenylquinazolin-4(3H)-one

chloroacetyl chloride

2-Phenyl-2,3-dihydro-benzo[e][1,3]oxazin-4-one

2-phenyl-4H-3,1-benzoxazin-4-one

Downstream raw materials:

C₁₉H₁₅N₅O₂

C₂₃H₁₇N₅O₂

C₂₄H₁₉N₅O₂

C₂₀H₁₇N₅O₂