9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine

Base Information

Chemical Name:9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine
CAS No.:141345-30-4
Molecular Formula:C₂₇H₃₃ClN₄O₇
Molecular Weight:561.035
Hs Code.:

Synonyms:9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine

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Chemical Property of 9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine

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Technology Process of 9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine

There total 3 articles about 9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5963-75-7
1-cyclohexyl-4-pentyne

: 5987-76-8
6-chloro-2-iodo-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine

: 141345-30-4
9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In 1,4-dioxane; for 1h; Ambient temperature;
DOI:10.1021/jm00090a017

Reference yield:

: 1124-63-6
3-cyclohexylpropan-1-ol

: 141345-30-4
9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / conc. H₂SO₄, 48percent HBr / 7 h / Heating

2: 59 percent / dimethylsulfoxide / 5 h / Ambient temperature

3: 91 percent / CuI, (PPh₃)2PdCl₂, Et₃N / dioxane / 1 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sulfuric acid; hydrogen bromide; triethylamine; In 1,4-dioxane; dimethyl sulfoxide;
DOI:10.1021/jm00090a017

Reference yield:

: 34094-21-8
(3-bromopropyl)cyclohexane

: 141345-30-4
9-(2,3,5-tri-O-acetyl-1-β-D-ribofuranosyl)-6-chloro-2-(5-cyclohexyl-1-pentyn-1-yl)purine

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / dimethylsulfoxide / 5 h / Ambient temperature

2: 91 percent / CuI, (PPh₃)2PdCl₂, Et₃N / dioxane / 1 h / Ambient temperature

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In 1,4-dioxane; dimethyl sulfoxide;
DOI:10.1021/jm00090a017