5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan

Base Information

Chemical Name:5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan
CAS No.:142873-41-4
Molecular Formula:C₂₄H₃₂N₂O
Molecular Weight:364.531
Hs Code.:

Synonyms:5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan

Suppliers and Price of 5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Technology Process of 5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan

There total 6 articles about 5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 771-99-3
4-phenylpiperidine

: 142873-46-9
2-bromomethyl-2,3-dihydro-2,4,6,7-tetramethyl-5-benzofuranamine

: 142873-41-4
5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan

Guidance literature:: With triethylamine; at 180 ℃; for 15h;
DOI:10.1021/jm960411j

Reference yield: 57.5%

: 142873-41-4
5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan

Guidance literature:

Reference yield:

: 99075-42-0
N-(4-hydroxy-2,3,6-trimethylphenyl)-formamide

: 142873-41-4
5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo[b]furan

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

2: 94 percent / N,N-diethylaniline / 3 h / 200 °C

3: 81 percent / Br₂, NaOAc / acetic acid / 0.17 h / Ambient temperature

4: 35percent aq. HCl / methanol / 2 h / Heating

5: 82 percent / Et₃N / 15 h / 180 °C

With hydrogenchloride; bromine; sodium acetate; potassium carbonate; triethylamine; N,N-diethylaniline; In methanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm960411j