N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide

Base Information

Chemical Name:N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide
CAS No.:1407870-39-6
Molecular Formula:C₁₄H₁₂F₇NO
Molecular Weight:343.244
Hs Code.:

Synonyms:N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide

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Chemical Property of N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide

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Technology Process of N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide

There total 2 articles about N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-89-5
Cyclohexanecarboxylic acid

: 1407870-39-6
N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: toluene / 16 h / 20 °C / Reflux

With oxalyl dichloride; In dichloromethane; toluene;
DOI:10.1021/ja309325e

Reference yield:

: 651-83-2
4-trifluoromethyl-2,3,5,6-tetrafluoroaniline

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1407870-39-6
N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide

Guidance literature:: In toluene; at 20 ℃; for 16h; Reflux;
DOI:10.1021/ja309325e

Reference yield: 84.0%

: 624-31-7
4-tolyl iodide

: 1407870-39-6
N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclohexanecarboxamide

: (1R,2S)-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-2-(p-tolyl)cyclohexane-1-carboxamide

Guidance literature:: With N-((1S,2S)-1-(3,5-di-tert-butylphenyl)-2-(quinolin-2-yl)propyl)acetamide; silver(I) acetate; palladium diacetate; silver carbonate; at 20 - 80 ℃; stereoselective reaction; Sealed tube;
DOI:10.1002/chem.201902046