3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide

Base Information

Chemical Name:3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide
CAS No.:1421755-89-6
Molecular Formula:C₁₈H₁₃ClN₄O₂S
Molecular Weight:384.846
Hs Code.:

Synonyms:3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide

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Chemical Property of 3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide

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Technology Process of 3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide

There total 3 articles about 3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1421755-85-2
ethyl 3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carboxylate

: 1421755-89-6
3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide

Guidance literature:: With hydrazine hydrate; In ethanol; for 3h; Reflux;
DOI:10.1007/s11164-012-1006-y

Reference yield:

: 120238-95-1
4-(4-chlorophenyl)-2-oxo-6-(thien-2-yl)-1,2-dihydropyridine-3-carbonitrile

: 1421755-89-6
3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h

1.2: 2 h / 20 °C

2.1: sodium methylate / methanol / 0.5 h / Reflux

3.1: hydrazine hydrate / ethanol / 3 h / Reflux

With sodium methylate; potassium carbonate; hydrazine hydrate; In methanol; ethanol; N,N-dimethyl-formamide; 2.1: |Thorpe Reaction;
DOI:10.1007/s11164-012-1006-y

Reference yield:

: 1421755-83-0
ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate

: 1421755-89-6
3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium methylate / methanol / 0.5 h / Reflux

2: hydrazine hydrate / ethanol / 3 h / Reflux

With sodium methylate; hydrazine hydrate; In methanol; ethanol; 1: |Thorpe Reaction;
DOI:10.1007/s11164-012-1006-y