Technology Process of methyl 4-hydroxy-2-methyl-2H-indazole-6-carboxylate
There total 6 articles about methyl 4-hydroxy-2-methyl-2H-indazole-6-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 4-methoxy-2-methyl-2H-indazole-6-carboxylate;
With
boron tribromide;
In
dichloromethane;
at 0 ℃;
for 48h;
With
sulfuric acid;
In
dichloromethane;
for 2h;
Reflux;
DOI:10.1016/j.bmcl.2012.09.082
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium diisopropyl amide; n-butyllithium / tetrahydrofuran / 2 h / -70 °C
2.1: methanol / 3.5 h / 0 °C / Reflux
3.1: hydrazine hydrate / ethylene glycol / 24 h / 95 °C
4.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / methanol / 24 h / 80 °C / 2585.81 Torr
5.1: trimethoxonium tetrafluoroborate / ethyl acetate / 16 h / 23 °C
6.1: boron tribromide / dichloromethane / 48 h / 0 °C
6.2: 2 h / Reflux
With
n-butyllithium; trimethoxonium tetrafluoroborate; palladium diacetate; boron tribromide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; hydrazine hydrate; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dichloromethane; ethylene glycol; ethyl acetate;
DOI:10.1016/j.bmcl.2012.09.082
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol / 3.5 h / 0 °C / Reflux
2.1: hydrazine hydrate / ethylene glycol / 24 h / 95 °C
3.1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine / methanol / 24 h / 80 °C / 2585.81 Torr
4.1: trimethoxonium tetrafluoroborate / ethyl acetate / 16 h / 23 °C
5.1: boron tribromide / dichloromethane / 48 h / 0 °C
5.2: 2 h / Reflux
With
trimethoxonium tetrafluoroborate; palladium diacetate; boron tribromide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; hydrazine hydrate; triethylamine;
In
methanol; dichloromethane; ethylene glycol; ethyl acetate;
DOI:10.1016/j.bmcl.2012.09.082
